53
Research Trials
20
Peer-reviewed publications
16
Clinical Conditions
Hyfe pilot study tests a digital therapeutic combining passive cough monitoring with behavioral suppression techniques delivered through the CoughPro app.
This narrative review by Hyfe's R&D team makes the case that continuous cough monitoring (CCM), powered by acoustic AI, transforms cough from a subjective symptom into a quantifiable digital biomarker.
Independent ERS 2025 NeuroCOUGH trial uses the Hyfe Cough Tracker to test feasibility of studying azithromycin's effect on cough and oesophageal motility.
Independent ERS 2025 trial uses the Hyfe Cough Tracker to show azithromycin reduces objective cough frequency by week one in chronic respiratory disease.
18.11.2025
This investigator-led feasibility trial from the NeuroCOUGH Clinical Research Collaboration tested whether a definitive study of azithromycin's effect on cough and oesophageal motility in chronic respiratory disease is achievable, pairing continuous cough monitoring with repeated high-resolution oesophageal manometry (HROM). Thirty patients with chronic cough and established respiratory disease were monitored continuously for one week before and four weeks during open-label azithromycin 250 mg daily using the Hyfe Cough Tracker, with HROM performed at baseline and at four weeks. Recruitment hit three patients per month at a single centre, 87% completed all visits, and every pre-specified data quality outcome met its stop-go criterion. Notably, 52% of patients had abnormal oesophageal function at baseline, and among those who underwent repeat HROM, 42% showed greater than 30% improvement in distal contractile integral after treatment. The findings establish feasibility for a definitive trial examining the gut-lung axis in respiratory disease and identify DCI as a viable outcome measure.
