53
Research Trials
20
Peer-reviewed publications
16
Clinical Conditions
Hyfe pilot study tests a digital therapeutic combining passive cough monitoring with behavioral suppression techniques delivered through the CoughPro app.
This narrative review by Hyfe's R&D team makes the case that continuous cough monitoring (CCM), powered by acoustic AI, transforms cough from a subjective symptom into a quantifiable digital biomarker.
Independent ERS 2025 NeuroCOUGH trial uses the Hyfe Cough Tracker to test feasibility of studying azithromycin's effect on cough and oesophageal motility.
Independent ERS 2025 trial uses the Hyfe Cough Tracker to show azithromycin reduces objective cough frequency by week one in chronic respiratory disease.
01.10.2024
The Hyfe Cough Monitor Suite allows for continuous, non-intrusive acoustic cough monitoring that can last for months. This allows the interpretation of longitudinal signals providing important insights for clinicians, researchers, drug developers and regulators. There were however concerns that coughs from non-user bystanders may contaminate the acoustic environment and skew the estimated cough rates.
We analysed 223 hours (almost 10 days) of monitoring submitted by non-coughing volunteers across ten different everyday environments. Acoustic contamination by non-participant coughs ranged from 0 coughs per hour in a restaurant/bar outdoors to 1.04 coughs per hour in a dense, indoor space (symposium) and the same rate for periods of grocery shopping.
Scenario 1 - office worker with a family: spends 8 hours sleeping at home with their partner, 8 hours in the office, 1 hour grocery shopping, 1 hour on public transportation, 1 hour in a restaurant, and 5 hours at home with family. They pick up 2.6 coughs from others in 24 hours.
Scenario 2 - business traveler: spends 7 hours sleeping at home with their partner, 5 hours on public transportation, 1 hour in a restaurant indoors, 1 hour in a bar outdoors, 5 hours at a symposium, 2 hours at home with family, and 3 hours alone in a hotel. They pick up 4.61 coughs from others in 24 hours.
This pilot study establishes a methodology for quantifying this phenomenon and offers preliminary evidence that non-user coughs have minimal impact on the cough estimates provided by the Hyfe Cough Monitor Watch in real-world settings.
